DSPE-PEG-Folate，DSPE-PEG-FA

商品型号：YZY2-DEFA-1K,2K,3K,5K,10K

英文简称：1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)]

分子量：1K,2K,3K,5K,10K

规格：100mg,500mg

DSPE-PEG-Folate，DSPE-PEG-FA

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethyleneglycol)]

Synonym: DSPE PEGFolate, Folic acid PEG DSPE

ProductStructure:

ProductSpecifications:

CatalogNumbers:PS2-DEFA-1K,2K,3K,5K,10K.

Appearance:Yellow,orange to brownish solid.

Solubility:>5mg/mL in hot water, chloroform/methanol, and DMSO.

Stability: 1 Years at-20°C, Desiccate.Protect from light.

CASNumber:1236288-25-7

MolecularWeight（PEG）:1K,2K,3.4K,5K,10K

Description:

DSPEPEG Folate, also called Folic acid PEG DSPE, is one of functional phospholipidPEG products provided by for targeted drug delivery, nanoparticlefunctionalization, liposome formation as well as many otherapplications.Pegylated phospholipid products demonstrate excellent amphilphilicproperties and offer superior advantages for small and large molecule targteddelivery. DSPE (1,2-distearoyl-sn-glycero-3-phosphophoethanolamine) PEG folicacid is a C18 phospholipid PEG derivative which can be used for folate receptortargeting. Folic acid is also known as vitamin M, vitamin B9 orpteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule fornumerous biological functions. It participates in the synthesis, repairing andmethylation of DNA as well as to act as a cofactor in many biologicalreactions.Pegylated DSPE and Folic acid is soluble both in organic solvents andaqueous buffer. They have been used for preparing folate receptor targetingliposome for either small molecules or large molecules delivery. Pegylation ofphospholipids significantly improves the blood circulation time and stabilityfor encapsulated drugs; it also suppresses the non-specific binding of chargedmolecules to the modified surfaces.

Handlingand Use:

DSPE-PEG-FA shouldalways be kept in low temperature in dry condition. Prepare fresh solutionright before use.

Avoid frequent thawand freezing. For more information about using this product,

RelatedProducts:

DSPE-PEG-NH2,DSPE-PEG-COOH

DSPE-PEG-NHS,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-MAL

References：

Bubble-generatingnano-lipid carriers for ultrasound/CT imaging-guided efficient tumor therapy------ InternationalJournal of Pharmaceutics（IF=3.862）

Nasopharyngealcancer combination chemoradiation therapy based on folic acid modified,gefitinib and yttrium 90 co-loaded, core-shell structured lipid-polymer hybridnanoparticles------ Biomedicine & Pharmacotherapy（IF=3.457）

Targeteddelivery of in situ PCR-amplified Sleeping Beauty transposon genes to cancercells with lipid-based nanoparticle-like protocells------ Biomaterials（IF=10.273）

Cancercell targeting, controlled drug release and intracellular fate of biomimeticmembrane-encapsulated drug-loaded nano-graphene oxide nanohybrids------ Journalof Materials Chemistry B（IF=4.776）

In vitroand in vivo evaluation of folate-mediated PEGylated nanostructured lipidcarriers for the efficient delivery of furanodiene.

NIRstimulus-responsive core–shell type nanoparticles based on photothermalconversion for enhanced antitumor efficacy through chemo-photothermal therapy------ Nanotechnology(IF=3.404)

lipidnanobubbles as an ultrasound-triggered artesunate delivery system forimaging-guided,tumor-targeted chemotherapy.

Facilesynthesis of biocompatible MoSe2 nanoparticles for efficienttargeted photothermal therapy of human lung cancer------ RSCAdvances（IF=2.963）

Inhalabledry powder prepared from folic acid-conjugated Docetaxel liposomes alterspharmacodynamic and pharmacokinetic properties relevant to lung cancerchemotherapy.

Nearinfrared radiated stimulus-responsive liposomes based on photothermalconversion as drug carriers for co-delivery of CJM126 and cisplatin------ MaterialsScience and Engineering C（IF=5.08）

NormalizingTumor Microenvironment Based on Photosynthetic Abiotic/Biotic Nanoparticles------ ACSNano（13.709）

A novelnear-infrared triggered dual-targeted nanoplatform for mitochondrial combinedphotothermal-chemotherapy of cancer in vitro------ Nanotechnology（3.404）

Folate-decoratedand NIR-triggered nanoparticles loaded with platinum(IV)-prodrug plus5-fluorouracil for targeted and chemo-photothermal combination therapy.

Paclitaxelprodrug based mixed micelles for tumor-targeted chemotherapy------ RSCAdvances（IF=2.963）

Thisproduct is for research use only and is not intended for use in humans or for diagnosticuse.