DSPE-PEG-Maleimide, DSPE-PEG-MAL

商品型号：YZY2-MDE-1K,2K,3K,5K,10K

英文简称：1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)]

分子量：1K,2K,3K,5K,10K

规格：500mg,1g

DSPE-PEG-Maleimide,DSPE-PEG-MAL

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethyleneglycol)]

Synonym: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethyleneglycol maleimide, Maleimide PEG DSPE.

ProductStructure:

ProductSpecifications:

CatalogNumbers:PS2-MDE-1K,2K,3K,5K,10K.

Appearance: Whiteto off-white or yellowish-white solid.

Solubility: >10mg/mL in hot water, chloroform, DCM, methanol.

Stability: 1 Years at-20°C, Desiccate.

CASNumber: 474922-22-0.

MolecularWeight（PEG）:1K,2K,3.4K,5K,10K.

Reactivegroup: Maleimide (-MAL).

Reactiveto: Sulfhydryl (-SH).

Purity: 95%.

Description:

DSPE PEG Maleimide is one of reactive phospholipid PEG derivatives that can react with sulfhydrylgroups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbonphospholipid that is highly hydrophobic. PEG backbone, on the other hand,offers good hydrophilicity and water solubility. Maleimide functionalized DSPEPEG has excellent reactivity towards sulfhydryl/thiol groups. Reaction betweenMaleimide and thiol group proceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactivephospholipids to conjugate antibodies, peptides or other ligands to the surfaceof liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longerblood circulation time and higher stability for encapsulated drugs. hasdeveloped a comprehensive collection of thiol reactive maleimide phospholipidPEG products that have high purity, various molecular weights and excellentchemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilicproperties and offer superior advantages for small and large molecule drugformulation and delivery.

Handlingand Use:

DSPEPEG Maleimide undergoes hydrolysis at elevated temperature andmoisture. Maleimide PEG should always be kept in low temperature in drycondition. Prepare fresh solution right before use. Avoid frequent thaw andfreezing. For more information about using this product,

RelatedProducts:

DSPE-PEG-NH2,DSPE-PEG-COOH

DSPE-PEG-NHS,DSPE-PEG-FA

DSPE-PEG-SH,DSPE-PEG-OPSS

References：

Afatinib-loadedImmunoliposomes Functionalized with Cetuximab: a Novel Strategy Targeting theEpidermal Growth Factor Receptor for Treatment of Non-small-cell Lung Cancer------ InternationalJournal of Pharmaceutics（IF=3.862）

Layer-by-LayerHeparinization of the Cell Surface by Using Heparin-Binding PeptideFunctionalized Human Serum Albumin------ Materials(IF=2.467)

Lifetime-engineeredNIR-II nanoparticles unlock multiplexed in vivo imaging------ NatureNanotechnology(IF=37.49)

MultifunctionalNanoparticles Enable Efficient Oral Delivery of Biomacromolecules via ImprovingPayload Stability and Regulating the Transcytosis Pathway------Acs applied materials&interfaces（IF=8.097）

Biomimeticvirus-like and charge reversible nanoparticles to sequentially overcome mucusand epithelial barriers for oral insulin delivery Acs applied materials&interfaces（IF=8.097）

Enhancedlegumain-recognition and NIR controlled released of cisplatin-indocyaninenanosphere against gastric carcinoma------ EuropeanJournal of Pharmacology（IF=3.04）

Thisproduct is for research use only and is not intended for use in humans or fordiagnostic use.